@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAY2_WA2mAiJkY534oJbNxKNxagREVfPZYjkqCgvdkdF4> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAY2_WA2mAiJkY534oJbNxKNxagREVfPZYjkqCgvdkdF4#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix schem: <http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 occursIn: mesh:D008099, mesh:D017667, mesh:D018482, species:10090;
    rdf:object go:0030073;
    rdf:predicate belv:increases;
    rdf:subject schem:serum%20insulin;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(SCHEM:\"serum insulin\") -> bp(GO:\"insulin secretion\")" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_3;
    pav:version "1.4" .
  
  sub:_2 prov:value "Two mechanisms have been identified to explain how insulin receptors promote insulin secretion in b cells. Insulin stimulates exocytosis of secretory vesicles (Aspinwall et al., 1999); exocytosis of insulin feeds back to promote transcription of the insulin gene, an effect mediated by insulin receptors, IRS2, and PI 3-kinase (Leibiger et al., 1998). This role for IRS2 in b cells helps to explain the observation that IRS2 knockout mice developed diabetes because of failure of insulin secretion to compensate for insulin resistance";
    prov:wasQuotedFrom pubmed:10199397 .
  
  sub:_3 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:10199397;
    prov:wasDerivedFrom beldoc:, sub:_2 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:29:46.754+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}