. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "complex(p(PFH:\"HDAC Class II Family\"),p(PFH:\"MEF2 Family\")) -| tscript(p(PFH:\"MEF2 Family\"))" . "kin(p(PFH:\"CAMK Family\")) -| (complex(p(PFH:\"HDAC Class II Family\"),p(PFH:\"MEF2 Family\")) -| tscript(p(PFH:\"MEF2 Family\")))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "The repression of MEF2 transcriptional activation by class II HDACs is regulated by the phosphorylation status of HDAC in a variety of cell types. Dephosphorylated HDAC remains within the nucleus and represses MEF2 activity. In response to activation of calmodulin-dependent protein kinase (CaMK), HDAC becomes phosphorylated (Kao et al., 2001). Phosphorylated HDAC binds to the chaperone protein 14-3-3 (Van Hemert et al., 2001) within the nucleus and moves out of the nucleus via the nuclear export protein CRM1 in complex with 14-3-3 (Grozinger and Schreiber, 2000; McKinsey et al., 2001)." . . "Selventa" . . . . "2014-07-03T14:30:33.450+02:00"^^ . . .