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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU#_3 http://www.w3.org/ns/prov#value Basigin, a transmembrane glycoprotein belonging to the immunoglobulin superfamily, has been shown to be essential for fertilization and implantation. The aim of this study was to determine the expression and hormonal regulation of basigin gene in mouse uterus during the peri-implantation period. Basigin immunostaining and mRNA were strongly localized in luminal and glandular epithelium on day 1 of pregnancy and gradually decreased to a basal level from day 2-4 of pregnancy. Basigin mRNA expression in the sub-luminal stroma was first detected on day 3 of pregnancy and increased on day 4 of pregnancy. On day 5 of pregnancy, the expression of basigin protein and mRNA was only detected in the implanting embryos, and the luminal epithelium and sub-luminal stroma surrounding the embryos. A similar expression pattern of basigin was also induced in the delayed-implantation uterus which was activated by estrogen injection. On day 6-8 of pregnancy, although a basal level of basigin protein was detected in the secondary decidual zone, basigin mRNA expression was strongly seen in this location. Basigin mRNA was also highly expressed in the decidualized cells under artificial decidualization. Estrogen significantly stimulated basigin expression in the ovariectomized mouse uterus. A high level of basigin immunostaining and mRNA was also seen in proestrus and estrus uteri. These results suggest that basigin expression is closely related to mouse implantation and up-regulated by estrogen. http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12211060 http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12211060 http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU#_3 http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU http://purl.org/dc/terms/created 2014-07-03T14:30:05.490+02:00 http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAY54vJy6x10F2hsOVe8iM9eyBCk9IIwUjwhhyEfeT3MU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234