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[We have recently shown that inhibition of aldose reductase (AR), an enzyme that catalyzes the reduction of lipid aldehydes and their glutathione conjugates, prevents human colon cancer cell growth in culture as well as in nude mouse xenografts by inhibiting the NF-?B-dependent activation of oxidative stress-mediated inflammatory and carcinogenic markers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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