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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYKMdPdgYiZA4Tww3ulZC1HrILHgbcMs5eiPpC4SWpCU#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAYKMdPdgYiZA4Tww3ulZC1HrILHgbcMs5eiPpC4SWpCU#_4 http://www.w3.org/ns/prov#value Whether this model represents an accelerated version of normal cancer progression, or simply a bypass of the premalignant stages, is still unclear. Human tumours that bypass premalignant stages have not been described. The importance of the angiogenic switch was also recently demonstrated by Weinberg and colleagues55. They showed that expression of the SV40 early region, TERT and activated RAS were sufficient to transform primary epithelial cells in vitro. 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