http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#Head http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#assertion http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#provenance http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#assertion http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:88562 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D007668 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_1 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=48432 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:"angiotensin II") -> r(MGI:Ctsd) http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_3 http://www.w3.org/ns/prov#value As a new line of inquiry into the molecular mechanisms underlying pathophysiological processes associated with angiotensin (ANG II)-dependent hypertension, we applied the method of serial analysis of gene expression (SAGE) to examine genome-wide transcription changes in the kidneys of mice that developed hypertension in response to chronic ANG II administration. Mice were infused subcutaneously via osmotic minipumps with ANG II for 7 days, and systolic blood pressure was measured by tail-cuff plethysmography. Subsequently, mice were euthanized, and the total RNA isolated from the kidneys was used to construct SAGE libraries. Comparison of 11,447 SAGE tags from the hypertensive kidneys, representing 5,740 unique transcripts, and 11,273 tags from the control kidneys, corresponding to 5,619 different transcripts, identified genes that are significantly (P upregulated in the hypertensive kidney. Our assessment of the genome-wide influence of ANG II resulted in the detection of several novel genes and in a recognition of potential new roles for the previously characterized genes, thus providing new probes with which to further explore the ANG II effects in normal and disease states. http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14570981 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14570981 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#_3 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM http://purl.org/dc/terms/created 2014-07-03T14:30:17.605+02:00 http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAYSxZI-ZWJjd5jCVu4g0Ckpmztrro-OOUUG34WIQqADM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234