http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#Head http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#assertion http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#provenance http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/Calcineurin%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9314 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/Calcineurin%20Complex http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_1 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:PPP3CA) hasComponent complex(NCH:"Calcineurin Complex") http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_3 http://www.w3.org/ns/prov#value We report the crystal structure of calcineurin (CN) in complex with CyPA-CsA at 2.8-A resolution. The CyPA-CsA complex binds to a composite surface formed by the catalytic and regulatory subunits of CN, where the complex of FK506 and its binding protein FKBP also binds. While the majority of the CN residues involved in the binding are common for both immunophilin-immunosuppressant complexes, a significant number of the residues are distinct. Unlike FKBP-FK506, CyPA-CsA interacts with Arg-122 at the active site of CN, implying direct involvement of CyPA-CsA in the regulation of CN catalysis. The simultaneous interaction of CyPA with both the composite surface and the active site of CN suggests that the composite surface may serve as a substrate recognition site responsible for the narrow substrate specificity of CN. The comparison of CyPA-CsA-CN with FKBP-FK506-CN significantly contributes to understanding the molecular basis of regulation of CN activity by the immunophilin-immunosuppressant. http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12218175 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12218175 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#_3 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8 http://purl.org/dc/terms/created 2014-07-03T14:30:05.551+02:00 http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAYfT7UTR3y4ikmJoAcA9psC1WeduBzTIF2QtfmSGdiU8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234