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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYfW-DSH4_QYLazOjIVfyX1U-2zNy0HmsFTIzY_ddkIg#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAYfW-DSH4_QYLazOjIVfyX1U-2zNy0HmsFTIzY_ddkIg#_5 http://www.w3.org/ns/prov#value Vasoactive intestinal peptide binding to VPAC(2) on CD4 T cells specifically induces an up-regulation of the Th2-type transcription factors c-Maf and JunB, which consequently enhances IL-4 and IL-5 production, leading to a Th2-type phenotype. There is strong evidence to support requirements for c-Maf, JunB, and NFAT in promoting IL-4 production. 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