http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#Head http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#assertion http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#provenance http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#assertion http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_2 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6881 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_3 http://www.selventa.com/vocabulary/variantOf http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3573 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.lgcstandards-atcc.org/Products/All/HTB-22.aspx http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_3 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_1 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(HGNC:MAPK8)) -> p(HGNC:FADD,pmod(P,S,194)) http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_5 http://www.w3.org/ns/prov#value We demonstrated here that long-term tamoxifen treatment causes G2/M cell cycle arrest through c-jun N-terminal kinase (JNK) activation, which is dependent on phosphorylation of Fas-associated death domain-containing protein (FADD) at 194 serine in an oestrogen (ER) receptor-positive breast cancer cell line, MCF-7. We conclude that JNK-mediated phosphorylation of FADD plays an important role in the negative regulation of cell growth and metastasis, independent of the ER status of a breast cancer, so that JNK/FADD signals might be promising targets for cancer therapy. http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16450001 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16450001 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#_5 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA http://purl.org/dc/terms/created 2014-07-03T14:30:41.355+02:00 http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAYlSHIgcBUNH4yGj1DYdlEQbmBKwd8BLGZ9gBFDVIMvA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234