@prefix this: . @prefix sub: . @prefix beldoc: . @prefix rdfs: . @prefix rdf: . @prefix xsd: . @prefix dct: . @prefix dce: . @prefix pav: . @prefix np: . @prefix belv: . @prefix prov: . @prefix go: . @prefix nch: . @prefix ProteinComplex: . @prefix hasAgent: . @prefix RNA: . @prefix hgnc: . @prefix geneProductOf: . @prefix species: . @prefix occursIn: . @prefix mesh: . @prefix pubmed: . @prefix orcid: . sub:Head { this: np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo; a np:Nanopublication . } sub:assertion { nch:Nfkb%20Complex a ProteinComplex: . sub:_1 hasAgent: nch:Nfkb%20Complex; a go:0042789 . sub:_2 geneProductOf: hgnc:12805; a RNA: . sub:_3 occursIn: mesh:D042783, species:9606; rdf:object sub:_2; rdf:predicate belv:increases; rdf:subject sub:_1; a rdf:Statement . sub:assertion rdfs:label "tscript(complex(NCH:\"Nfkb Complex\")) -> r(HGNC:XDH)" . } sub:provenance { beldoc: dce:description "Approximately 61,000 statements."; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved."; dce:title "BEL Framework Large Corpus Document"; pav:authoredBy sub:_5; pav:version "1.4" . sub:_4 prov:value "Throughout evolution, pathogen-induced stimulation of the innate immune system relies on numerous conserved Toll-like receptors (TLRs), which initiate intracellular signaling cascades that subsequently activate the transcription factors NF-B and AP-1 [43 and 44]. NF-B controls a wide variety of immune-inducible antimicrobial molecules, including ROS and RNS, as well as cytokines and co-stimulatory molecules [45]. Binding sites for NF-B and AP-1, as well as for response elements for cytokines, have been identified in the 5' UTR (untranslated region) of the human XOR gene and both NF-B and XOR are stimulated by bacterial lipopolysaccharids (LPS) in vivo [28, 46 and 47]. This suggests that XOR is a downstream target of the TLR-NF-B pathway and is directly activated by NF-B and AP-1."; prov:wasQuotedFrom pubmed:12967676 . sub:_5 rdfs:label "Selventa" . sub:assertion prov:hadPrimarySource pubmed:12967676; prov:wasDerivedFrom beldoc:, sub:_4 . } sub:pubinfo { this: dct:created "2014-07-03T14:30:16.440+02:00"^^xsd:dateTime; pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 . }