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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo#_4 http://www.w3.org/ns/prov#value Throughout evolution, pathogen-induced stimulation of the innate immune system relies on numerous conserved Toll-like receptors (TLRs), which initiate intracellular signaling cascades that subsequently activate the transcription factors NF-B and AP-1 [43 and 44]. NF-B controls a wide variety of immune-inducible antimicrobial molecules, including ROS and RNS, as well as cytokines and co-stimulatory molecules [45]. Binding sites for NF-B and AP-1, as well as for response elements for cytokines, have been identified in the 5' UTR (untranslated region) of the human XOR gene and both NF-B and XOR are stimulated by bacterial lipopolysaccharids (LPS) in vivo [28, 46 and 47]. This suggests that XOR is a downstream target of the TLR-NF-B pathway and is directly activated by NF-B and AP-1. http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12967676 http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12967676 http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo#_4 http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo http://purl.org/dc/terms/created 2014-07-03T14:30:16.440+02:00 http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAYocHe-A8U73NMr1ItP2a9q5mC3mzHVu28JSeixAqWlo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234