http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#Head http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#assertion http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#provenance http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#assertion http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=13518 http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://purl.bioontology.org/ontology/MSH/D017209 http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_1 http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:CLIC4) -| bp(MESHPP:Apoptosis) http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_3 http://www.w3.org/ns/prov#value Chloride intracellular channel (CLIC)4 is a p53- and tumor necrosis factor alpha (TNFalpha)-regulated chloride channel protein that is localized to the mitochondria and cytoplasm of mouse and human keratinocytes. CLIC4 protein increases in differentiating keratinocytes and in keratinocytes exposed to DNA-damaging agents and metabolic inhibitors. Increasing CLIC4 levels by transduction of recombinant CLIC4 causes apoptosis. CLIC4 translocates to the nucleus under a variety of conditions of cell stress, and nuclear CLIC4 is associated with cell cycle arrest and accelerated apoptosis. Reduction of CLIC4 and several other CLIC family members by expressing a doxycycline-regulated CLIC4 antisense also causes apoptosis in squamous cancer cell lines. Expressing antisense CLIC4 in tumors derived from transplanting these cells into nude mice inhibits tumor growth, increases tumor apoptosis, and reduces tumor cell proliferation. Co-administration of TNFalpha intraperitoneally enhances the tumor-inhibitory influence of CLIC4 antisense expression. Together, these results suggest that CLIC4 is important for keratinocyte viability and may be a novel target for anti-cancer therapy. http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16358817 http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16358817 http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#_3 http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4 http://purl.org/dc/terms/created 2014-07-03T14:30:40.188+02:00 http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAYq1BkLYOxp53C3v48ikK05lxR_qVd6vgoJcd6AENem4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234