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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0#_5 http://www.w3.org/ns/prov#value Because these residues are required for enhanced MEF2C activity in monocytic cells, we tested whether MyoD activation of Gal4-MEF2C required the same amino acids. The combined mutation of both Thr293 and Thr300 to alanine (T293;300A) did not affect the basal activity of Gal4-MEF2C (Figure 3b, compare columns 3 and 5), but did enhance the activity of Gal4-MEF2C when MyoD+E12 were co-expressed (Figure 3b, compare columns 4 and 6). In contrast, mutation of Ser387 to alanine (S387A) decreased the basal activity of Gal4-MEF2C and completely eliminated its activation by co-transfected MyoD+E12 (Figure 3b, columns 7,8). Importantly, activation of the p38 kinase pathway did stimulate the function of the S387A Gal4-MEF2C mutant (data not shown; see also [25,27]), indicating that this mutation does not simply inactivate the protein. Therefore, MyoD activation of the MEF2C TAD requires Ser387, but neither Thr293 nor Thr300, of MEF2C. http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10322110 http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10322110 http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0#_5 http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0 http://purl.org/dc/terms/created 2014-07-03T14:29:47.083+02:00 http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAZ0UjlXaVw1knTmShJGQe3xlMfhzq-BkzRbxMwm66YF0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234