. . . . . . . . . . . . . . "p(HGNC:TNF) -> p(HGNC:SMPD1)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Treatment of U937 cells with TNF-alpha for 5 min increased the intracellular concentration of ceramide, however it was prevented by incubation with D609 (which inhibits acidic Sphingomyelinase activity). Further showed that D609 also inhibited the TNF-alpha induced apoptosis. This suggests that TNF-alpha induced ceramide generation and apoptosis were mediated by sphingomyelinase." . . "Selventa" . . . . "2014-07-03T14:29:50.896+02:00"^^ . . .