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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM#_4 http://www.w3.org/ns/prov#value Treatment of U937 cells with TNF-alpha for 5 min increased the intracellular concentration of ceramide, however it was prevented by incubation with D609 (which inhibits acidic Sphingomyelinase activity). Further showed that D609 also inhibited the TNF-alpha induced apoptosis. This suggests that TNF-alpha induced ceramide generation and apoptosis were mediated by sphingomyelinase. http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10792026 http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10792026 http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM#_4 http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM http://purl.org/dc/terms/created 2014-07-03T14:29:50.896+02:00 http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAZF9RxvWE7aovlEPKwNRbFhB9R3IsCs6F8pn0xsBIJGM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234