@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAZNmDe1ENg9o73m5eNAfs-W3tNKZRd3ocuyvFYcz8Mek> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAZNmDe1ENg9o73m5eNAfs-W3tNKZRd3ocuyvFYcz8Mek#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 hasAgent: sub:_2 ;
    a go:0042789 .
  sub:_2 geneProductOf: hgnc:7978 ;
    a Protein: .
  sub:_3 hasAgent: sub:_4 ;
    a go:0016301 .
  sub:_4 geneProductOf: hgnc:6091 ;
    a Protein: .
  sub:_5 hasAgent: sub:_6 ;
    a go:0016301 .
  sub:_6 geneProductOf: hgnc:4617 ;
    a Protein: .
  sub:_7 rdf:object sub:_5 ;
    rdf:predicate belv:decreases ;
    rdf:subject sub:_3 ;
    a rdf:Statement .
  sub:_8 occursIn: mesh:D018482 , species:9606 ;
    rdf:object sub:_7 ;
    rdf:predicate belv:decreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "kin(p(HGNC:INSR)) -| kin(p(HGNC:GSK3B))" , "tscript(p(HGNC:NR3C1)) -| (kin(p(HGNC:INSR)) -| kin(p(HGNC:GSK3B)))" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_10 ;
    pav:version "1.4" .
  sub:_10 rdfs:label "Selventa" .
  sub:_9 prov:value "Dexamethasone treatment decreased the ability of insulin to stimulate glucose uptake, glycogen synthesis and glycogen synthase fractional activity. In addition, the dephosphorylation of glycogen synthase by insulin was blocked. These defects were paralleled by reduced insulin-stimulated protein kinase B (PKB) and GSK-3 phosphorylation. We demonstrated that chronic dexamethasone treatment impairs insulin-stimulated PKB and GSK-3 phosphorylation, which may contribute to insulin resistance in skeletal muscles." ;
    prov:wasQuotedFrom pubmed:16078016 .
  sub:assertion prov:hadPrimarySource pubmed:16078016 ;
    prov:wasDerivedFrom beldoc: , sub:_9 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:30:37.187+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}