sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "1.4" .
  sub:_5 prov:value "Orlistat reduced phosphorylation of the Rb protein, up-regulated p27Kip1, and down-regulated Skp2. These effects were evident at levels of the drug consistent with the cellular IC50 of Orlistat for inhibition of the FAS thioesterase (1-3 M). To independently verify that the effects of Orlistat could be attributed to its ability to block FAS, similar experiments were conducted with siRNA-targeting FAS (Fig. 4B). Like Orlistat, the siRNA-targeting FAS decreased the phosphorylation of Rb, increased the level of p27Kip1, and reduced the level of Skp2. An siRNA-targeting Skp2 had identical effects upon its downstream target, p27Kip1, and upon the phosphorylation status of the Rb protein. Together, these findings provide strong support for the idea that a FAS blockade acts upon the Rb pathway via regulation of Skp2 and also indicate that a FAS blockade is likely to have effects similar to an Skp2 blockade." ;
    prov:wasQuotedFrom pubmed:15138278 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15138278 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}