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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w#_6 http://www.w3.org/ns/prov#value In this study, we found that a flavoprotein, NADPH-P450 reductase (NPR), could regulate the induction of EPO mRNA under hypoxic conditions. Hypoxic EPO mRNA induction in Hep3B cells was inhibited by diphenyleneiodonium chloride, which is an inhibitor of NADPH-dependent enzymes. NPR antisense cDNA was transfected into Hep3B cells, and NPR-deficient hepatocyte cells (NPR(-) cells) were established. NPR(-) cells lacked EPO induction under hypoxia, and HIF-1alpha in NPR(-) cells did not respond to either transcriptional activation or translocation to the nucleus based on electrophoretic mobility shift assays and reporter gene assay including hypoxia response element. http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11971899 http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11971899 http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w#_6 http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w#pubinfo http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w http://purl.org/dc/terms/created 2014-07-03T14:30:02.698+02:00 http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAZjOTXD3-DEfA8REfYlXhTS3UIZdcngP8r1CA4un5L-w http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234