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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg#_4 http://www.w3.org/ns/prov#value The SJL mouse is a model for human dysferlinopathy (limb-girdle muscular dystrophy type 2B and Miyoshi myopathy). We used cDNA microarrays to compare the expression profiles of 10,012 genes in control and SJL quadriceps femoris muscles in order to find genes involved in the degeneration and regeneration process and in dysferlin's functional network. Many genes involved in the process of muscle regeneration are observed to be up-regulated in SJL mice, including cardiac ankyrin repeated protein (CARP), Neuraminidase 2, interleukin-6, insulin-like growth factor-2 and osteopontin. We found the upregulation of S100 calcium binding proteins, neural precursor cell expressed, developmentally down-regulated gene 4-like (NEDD4L) with C2 domain, and intracellular protein traffic associated proteins (Rab6 and Rab2). These proteins have the potential to interact with dysferlin. We must reveal some other molecules which may work with dysferlin in order to clarify the pathological network of dysferlinopathy. This process may lead to future improvements in the therapy for human dysferlinopathy. http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15811552 http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15811552 http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg#_4 http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg http://purl.org/dc/terms/created 2014-07-03T14:30:33.837+02:00 http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAZkyNubSe5qENlObFDAqabx3GLuoDUCjClzTrzdciHZg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234