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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc#_3 http://www.w3.org/ns/prov#value Despite such multiple target interactions of Akt1, parallel coinhibition of Akt1 and Par-4 expression by RNA interference resulted in the inhibition of apoptosis, indicating the failure of the other Akt1 substrates to induce apoptosis in the absence of Par-4 expression or function. Moreover, coinhibition of Akt1 and other Akt1 substrates did not inhibit apoptosis, implying that the observed apoptosis upon Akt1 inhibition can be ascribed primarily to Par-4. These observations highlight both the significance of Akt1 inhibition of endogenous Par-4 to promote cancer cell survival and the Par-4 dependent nature of apoptosis upon inhibition of Akt1 (Fig. 1B). http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16540633 http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16540633 http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc#_3 http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc http://purl.org/dc/terms/created 2014-07-03T14:30:42.023+02:00 http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAZmZIc6L-_fe7TcikJ2Uq8wWSXk8YB1RL6bkRNd3KDSc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234