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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw#_3 http://www.w3.org/ns/prov#value Studies described here utilize high-density oligonucleotide arrays to characterize changes in global mRNA expression patterns during proliferation, cell cycle withdrawal, and terminal differentiation in mouse C2C12 myoblasts. Statistical analyses revealed 629 sequences differentially regulated between proliferating and differentiating myoblasts. These genes were clustered using self-organizing maps to identify sets of coregulated genes and were assigned to functional categories that were analyzed for distribution across expression clusters. Clusters were identified with statistically significant enrichment of functional categories including muscle contraction, cell adhesion, extracellular matrix function, cellular metabolism, mitochondrial transport, DNA replication, cell cycle control, mRNA transcription, and unexpectedly, immune regulation. In addition, functional category enrichment data can be used to predict gene function for numerous differentially regulated expressed sequence tags. The results provide new insight into how genes involved in these cellular processes may play a role in skeletal muscle growth and differentiation. http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12181367 http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12181367 http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw#_3 http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw http://purl.org/dc/terms/created 2014-07-03T14:30:05.075+02:00 http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAZsuSwWR42b2dejgJDP6g0SsYh5n3cFs77MaSNVOIJNw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234