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p(MGI:Mesp2) -| r(MGI:Uncx)
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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1.4
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We have analyzed the enhancer region of Epha4, which is responsible for its expression in the anterior PSM, and identified an E-box containing region. Subsequent transgenic and transient luciferase analyses successfully determined that the presence of repeated E-box sequences is a minimum essential requirement for the expression in the anterior PSM. We also show that Mesp2 directly binds to the enhancer sequence of Epha4. Furthermore, the forced expression of Mesp2 in somitic cells results in the activation of Epha4 and repression of the caudal gene Uncx4.1
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Selventa
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2014-07-03T14:30:43.231+02:00
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