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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA_CPaKXjDhunIFjVt5odUZst1bXZruBGJuxIPabWqj5M#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA_CPaKXjDhunIFjVt5odUZst1bXZruBGJuxIPabWqj5M#_2 http://www.w3.org/ns/prov#value Addition of a sulfonylurea to metformin therapy gives an additive glucose- lowering effect (102, 103,149). Similarly, addition of metformin to sulfonylurea therapy gives an additive response, both with respect to glucose-lowering (101, 103, 149-152) and lipid-lowering (91, 103) effects the elevated fasting plasma glucose level is caused by incomplete suppression of basal hepatic glucose production by sulfonylurea or metformin Figure 1. Pathogenesis of type 2 diabetes mellitus. Sites of action of oral agents are indicated. 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