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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA_INNTVZhZfHXJhBVdtak8Oa4dFBJGQa_A5WuBalEvRk#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA_INNTVZhZfHXJhBVdtak8Oa4dFBJGQa_A5WuBalEvRk#_5 http://www.w3.org/ns/prov#value Two types of receptors have been identified for FGF-2: high affinity tyrosine-kinase FGF receptors (FGFRs) (123) and low affinity heparan sulfate proteoglycans (HSPGs). Thus far, at least four members of FGFRs have been identified. They represent low number (approx. 10,000 per cell), but high affinity sites (Kd of 20-600 pM). Low affinity binding sites (Kd of 2-20 nM) with high capacity (approx. 1 million sites per cell) were identified as proteoglycans, including syndecan and perlecan, containing heparan sulfate side chains (202). These HSPGs are found in the ECM, the basement membrane and the cell surface. 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