@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 hasAgent: sub:_2 ;
    a go:0003824 .
  sub:_2 hasPart: sub:_3 , sub:_4 ;
    a ProteinComplex: .
  sub:_3 geneProductOf: mgi:1929183 ;
    a Protein: .
  sub:_4 geneProductOf: mgi:102548 ;
    a Protein: .
  sub:_5 occursIn: species:10090 ;
    rdf:object sub:_1 ;
    rdf:predicate belv:decreases ;
    rdf:subject go:0001666 ;
    a rdf:Statement .
  sub:assertion rdfs:label "bp(GO:\"response to hypoxia\") -| cat(complex(p(MGI:Tsc1),p(MGI:Tsc2)))" .
}
sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_7 ;
    pav:version "1.4" .
  sub:_6 prov:value "Here we show that mTOR inhibition by hypoxia requires the TSC1/TSC2 tumor suppressor complex and the hypoxia-inducible gene REDD1/RTP801. Disruption of the TSC1/TSC2 complex through loss of TSC1 or TSC2 blocks the effects of hypoxia on mTOR, as measured by changes in the mTOR targets S6K and 4EBP1, and results in abnormal accumulation of Hypoxia-inducible factor (HIF)." ;
    prov:wasQuotedFrom pubmed:15545625 .
  sub:_7 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15545625 ;
    prov:wasDerivedFrom beldoc: , sub:_6 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:30:29.589+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}