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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw#_6 http://www.w3.org/ns/prov#value Here we show that mTOR inhibition by hypoxia requires the TSC1/TSC2 tumor suppressor complex and the hypoxia-inducible gene REDD1/RTP801. Disruption of the TSC1/TSC2 complex through loss of TSC1 or TSC2 blocks the effects of hypoxia on mTOR, as measured by changes in the mTOR targets S6K and 4EBP1, and results in abnormal accumulation of Hypoxia-inducible factor (HIF). http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15545625 http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15545625 http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw#_6 http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw http://purl.org/dc/terms/created 2014-07-03T14:30:29.589+02:00 http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAa15B9aF6hr2qyN0BCQz5UTudwdiSDIH1NT2jN-57fkw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234