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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAa4G9wdxD8-Z8mELsfnzmkNKDRKbg1t6Gqlr0mzU7wg8#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAa4G9wdxD8-Z8mELsfnzmkNKDRKbg1t6Gqlr0mzU7wg8#_4 http://www.w3.org/ns/prov#value Notch1 function in mouse skin. Representation of mammalian skin with several layers of differentiating cells, and some proteins that are expressed in specific cellular layers. After differentiation signals are received, Notch1 induces expression of involucrin, keratin-1 (K1) and the cell-cycle inhibitor Waf1, and prevents the onset of fillagrin and loricrin expression until the cell is at later stages of differentiation. Both ?-catenin-mediated Wnt signalling and Gli2-mediated Sonic-hedgehog signalling are normally repressed in the murine epidermis by Notch1. 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