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[Cdk4 in association with its D-type cyclin partners, together with p16Ink4, and the product of the retinoblastoma tumour-suppressor gene (pRB), appear to constitute a G1-phase-controlling pathway which can become de-regulated through oncogenic aberrations of any of the components.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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