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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8#_5 http://www.w3.org/ns/prov#value Extensive data indicate that oncoproteins, such as oncogenic H-Ras, initiate signal transduction cascades that ultimately lead to the activation of specific transcription factors. We and others have previously demonstrated that Ras activates the inherent transcriptional activation function of the transcription factor nuclear factor kappaB (NF-kappaB). Supportive of the importance of NF-kappaB in transformation, Ras-induced cellular transformation can be suppressed by expression of IkappaBalpha, an inhibitor of NF-kappaB, or by dominant-negative forms of the upstream activator IkappaB kinase (IKK). However, conclusive evidence for a requirement for NF-kappaB subunits in oncogenic transformation has not been reported. Furthermore, there is little understanding of the gene targets controlled by NF-kappaB that might support oncogenic conversion. The data presented here demonstrate that, although both p65 and c-Rel enhance the frequency of Ras-induced cellular transformation, these NF-kappaB subunits are not essential for Ras to transform spontaneously immortalized murine fibroblasts. Microarray analysis identified a set of genes induced by Ras that is dependent on NF-kappaB for their expression and that likely play contributory roles in promoting Ras-induced oncogenic transformation. http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15492243 http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15492243 http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8#_5 http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8 http://purl.org/dc/terms/created 2014-07-03T14:30:28.733+02:00 http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAaC23zMqN6m9R0TQVUtya-4vtBWWhc27E8DkSVya6Yq8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234