http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#Head http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#assertion http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#provenance http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#assertion http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_1 http://purl.obolibrary.org/obo/RO_0002204 http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=2802 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D008099 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_1 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=50867 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:ciprofibrate) -> r(RGD:Hmgb1) http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_3 http://www.w3.org/ns/prov#value Fibrate class hypolipidemic drugs such as ciprofibrate activate the peroxisome proliferator-activated receptor-alpha (PPARalpha), which is involved in processes including lipid metabolism and hepatocyte proliferation in rodents. We examined the effects of ciprofibrate (50 mg/kg body wt per day for 60 days) on liver gene expression in rats using cDNA microarrays. The 60-day dosing period was chosen to elucidate both the metabolic and proliferative actions of this substance, while avoiding confounding effects from the hepatic carcinogenesis seen during more long-term stimulation. Ciprofibrate changed the expression of many genes including previously known PPARalpha agonist-responsive genes involved in processes such as lipid metabolism and inflammatory responses. In addition, many novel candidate genes involved in sugar metabolism, transcription, signal transduction, cell proliferation, and stress responses appeared to be differentially regulated in ciprofibrate-dosed rats. Ciprofibrate also resulted in significant increases in liver weight and hepatocyte proliferation. The cDNA microarray results were confirmed by Northern blot analysis for selected genes. This study thus identifies many genes that appear to be differentially regulated in ciprofibrate-dosed rats, and some of these are potential targets of PPARalpha. The functional diversity of these candidate genes suggests that most of them are likely to be differentially regulated as indirect consequence of the many processes affected by ciprofibrate in rodent liver. Although caution is advisable in the interpretation of genome-wide expression data, the genes identified in the present study provide candidates for further studies that may give new insight into the mechanisms of action of peroxisome proliferators. http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12851464 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12851464 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#_3 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA http://purl.org/dc/terms/created 2014-07-03T14:30:14.540+02:00 http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAaLZ4aTOHa5xSFchvserAsB_KpV-KNuYWGEkqjedATRA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234