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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI#_5 http://www.w3.org/ns/prov#value The role of the cystic fibrosis transmembrane conductance regulator (CFTR) in the renal cortical collecting duct (CCD) has not yet been fully elucidated. Here, we investigated the effects of deamino-8-D-arginine vasopressin (dDAVP) and isoproterenol (ISO) on NaCl transport in primary cultured CCDs microdissected from normal [CFTR(+/+)] and CFTR-knockout [CFTR(-/-)] mice. dDAVP stimulated the benzamyl amiloride (BAm)-sensitive transport of Na(+) assessed by the short-circuit current (I(sc)) method in both CFTR(+/+) and CFTR(-/-) CCDs to a very similar degree. Apical addition of 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB) or glibenclamide partially inhibited the rise in I(sc) induced by dDAVP and ISO in BAm-treated CFTR(+/+) CCDs, whereas dDAVP, ISO, and NPPB did not alter I(sc) in BAm-treated CFTR(-/-) CCDs. dDAVP stimulated the apical-to-basal flux and, to a lesser extent, the basal-to-apical flux of (36)Cl(-) in CFTR(+/+) CCDs. dDAVP also increased the apical-to-basal (36)Cl(-) flux in CFTR(-/-) CCDs but not the basal-to-apical (36)Cl(-) flux. These results demonstrate that CFTR mediates the cAMP-stimulated component of secreted Cl(-) in mouse CCD. http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11502593 http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11502593 http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI#_5 http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI http://purl.org/dc/terms/created 2014-07-03T14:29:57.833+02:00 http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAaSvkRohlz7ZpSiRqXbSNUhh2zuQusQUpc7ZPN2LGQDI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234