[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_1", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=18142" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3086" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_3", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0005525" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_4", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=667" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_5", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_3" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_2" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_6", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_5" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "p(HGNC:DAAM1) -> (p(HGNC:DVL2) -> gtp(p(HGNC:RHOA)))" }, { "@value" : "p(HGNC:DVL2) -> gtp(p(HGNC:RHOA))" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_8" } ], "http://purl.org/pav/version" : [ { "@value" : "1.4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_7", "http://www.w3.org/ns/prov#value" : [ { "@value" : "DAAM1 IS REQUIRED FOR WNT/FZ/DVL ACTIVATION OF RHO We next examined whether Daam1 function is required for Rho activation by Wnt/Fz/Dvl signaling. Since either N-Daam1 or T-Daam1 disrupts the Dvl-Rho complex formation, they may represent dominant negative Daam1 mutants. Indeed, either N-Daam1 or T-Daam1, which do not induce RhoA activation, blocks RhoA activation by Wnt-1 CM, Fz, or Dvl, but not by Ephexin (Figures 3A and 3B and not shown), suggesting that Daam1 function is specifically required downstream of Dvl in Wnt/Fz activation of Rho." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/11779461" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_8", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/11779461" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_7" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:30:00.070+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#pubinfo" } ]