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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_7 http://www.w3.org/ns/prov#value DAAM1 IS REQUIRED FOR WNT/FZ/DVL ACTIVATION OF RHO We next examined whether Daam1 function is required for Rho activation by Wnt/Fz/Dvl signaling. Since either N-Daam1 or T-Daam1 disrupts the Dvl-Rho complex formation, they may represent dominant negative Daam1 mutants. Indeed, either N-Daam1 or T-Daam1, which do not induce RhoA activation, blocks RhoA activation by Wnt-1 CM, Fz, or Dvl, but not by Ephexin (Figures 3A and 3B and not shown), suggesting that Daam1 function is specifically required downstream of Dvl in Wnt/Fz activation of Rho. http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11779461 http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11779461 http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#_7 http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA http://purl.org/dc/terms/created 2014-07-03T14:30:00.070+02:00 http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAaeOi4GgyMAtI9frOn_a1Fznu6e3GPj9CgBPTHtuAjHA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234