http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#Head http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#assertion http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#provenance http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#pubinfo http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_1 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_2 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-protein-families/Hsp90%20Family http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_2 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_1 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#assertion http://www.w3.org/2000/01/rdf-schema#label kin(complex(NCM:"p85/p110 PI3Kinase Complex")) -> p(PFM:"Hsp90 Family") http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_4 http://www.w3.org/ns/prov#value Considering that PI3K inhibitors down-regulated heat shock protein 90 (Hsp90) as well as Hsp70 expression and moreover attenuated heat- or hypoxia-induced Hsp70 as well as hypoxia-induced Hsp90 up-regulation we conclude that PI3K inhibition promoted degradation of HIF-1alpha indirectly by reducing steady state concentrations of Hsp90 and/or Hsp70. http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14726529 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14726529 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#_4 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso#pubinfo http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso http://purl.org/dc/terms/created 2014-07-03T14:30:19.817+02:00 http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAafZU9_a4GHIswakJuzX9JUXu7aoT3-BKXbxSgfkiJso http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234