sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_9 ;
    pav:version "1.4" .
  sub:_8 prov:value "PMID 10620507 We found previously that protein kinase C-z (PKC-z) can phosphorylate and activate Raf-1 in a signalling complex. We report now that PKCz-Raf-1 interaction is mediated by 14-3-3 proteins in ?itro and in ?i?o. the results suggest that 14-3-3 binds both PKC-z (at phospho-Ser-186) and Raf-1 ina ternary complex. Complex formation was much stronger with a kinase-inactive PKC-z mutant than with wild-type PKC-z, supporting the idea that kinase activity leads to complex dissociation 14-3-3B and Q with its putative PKCz phosphorylation sites mutated enhanced co-precipitation between PKC-z and Raf-1, suggesting that phosphorylation of 14-3-3 by PKC-z weakens the complex in in vivo" ;
    prov:wasQuotedFrom pubmed:10433554 .
  sub:_9 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:10433554 ;
    prov:wasDerivedFrom beldoc: , sub:_8 .
}