[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_1", "@type" : [ "http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000", "http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696" ], "http://www.selventa.com/vocabulary/variantOf" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=1785" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=1785" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_3", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_2" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/decreases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "p(HGNC:CDKN1B,pmod(P,T,187)) -| p(HGNC:CDKN1B)" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_5" } ], "http://purl.org/pav/version" : [ { "@value" : "1.4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_4", "http://www.w3.org/ns/prov#value" : [ { "@value" : "Loss of p27kip1 expression in cancer primarily occurs through sustained protein degradation, a four-step process that requires phosphorylation of p27kip1 at threonine 187 by cyclin E/cdk, recognition of T187-phosphorylated p27kip1 by the ubiquitin ligase SCFSkp2, ubiquitylation, and degradation by the 26S proteasome of T187-phosphorylated p27kip1. Cytoplasmic retention of p27kip1 may occur through increased export or reduced import. Interaction of p27kip1 with JAB1/CNS5 or phosphorylation of serine 10 (S10) by the hKIS kinase promotes p27kip1 export from the nucleus, whereas phosphorylation of threonine 157 (T157) by the protein kinase B/AKT (AKT) impairs its import." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/15743786" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_5", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/15743786" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_4" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:30:33.235+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#pubinfo" } ]