. . . . . . . . . . . . . . "p(HGNC:CDKN1B,pmod(P,T,187)) -| p(HGNC:CDKN1B)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Loss of p27kip1 expression in cancer primarily occurs through sustained protein degradation, a four-step process that requires phosphorylation of p27kip1 at threonine 187 by cyclin E/cdk, recognition of T187-phosphorylated p27kip1 by the ubiquitin ligase SCFSkp2, ubiquitylation, and degradation by the 26S proteasome of T187-phosphorylated p27kip1. Cytoplasmic retention of p27kip1 may occur through increased export or reduced import. Interaction of p27kip1 with JAB1/CNS5 or phosphorylation of serine 10 (S10) by the hKIS kinase promotes p27kip1 export from the nucleus, whereas phosphorylation of threonine 157 (T157) by the protein kinase B/AKT (AKT) impairs its import." . . "Selventa" . . . . "2014-07-03T14:30:33.235+02:00"^^ . . .