http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#Head http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#assertion http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#provenance http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#assertion http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_1 http://www.selventa.com/vocabulary/variantOf http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=1785 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=1785 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_2 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_1 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:CDKN1B,pmod(P,T,187)) -| p(HGNC:CDKN1B) http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_4 http://www.w3.org/ns/prov#value Loss of p27kip1 expression in cancer primarily occurs through sustained protein degradation, a four-step process that requires phosphorylation of p27kip1 at threonine 187 by cyclin E/cdk, recognition of T187-phosphorylated p27kip1 by the ubiquitin ligase SCFSkp2, ubiquitylation, and degradation by the 26S proteasome of T187-phosphorylated p27kip1. Cytoplasmic retention of p27kip1 may occur through increased export or reduced import. Interaction of p27kip1 with JAB1/CNS5 or phosphorylation of serine 10 (S10) by the hKIS kinase promotes p27kip1 export from the nucleus, whereas phosphorylation of threonine 157 (T157) by the protein kinase B/AKT (AKT) impairs its import. http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15743786 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15743786 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#_4 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk http://purl.org/dc/terms/created 2014-07-03T14:30:33.235+02:00 http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAbONhxslUhy9Xg1Drz8JsfrBrzusKWXzHofHYRjBqYYk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234