@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAbVfIVjdyxKwDsoulM2PAl3kCo2mTlQh8tiHzyShzI9Y> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAbVfIVjdyxKwDsoulM2PAl3kCo2mTlQh8tiHzyShzI9Y#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasPart: sub:_2, sub:_3;
    a ProteinComplex: .
  
  sub:_2 geneProductOf: hgnc:10500;
    a Protein: .
  
  sub:_3 geneProductOf: hgnc:320;
    a Protein: .
  
  sub:_4 hasAgent: sub:_5;
    a go:0003824 .
  
  sub:_5 geneProductOf: hgnc:320;
    a Protein: .
  
  sub:_6 occursIn: species:9606;
    rdf:object sub:_4;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "complex(p(HGNC:S100B),p(HGNC:AGER)) => cat(p(HGNC:AGER))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_8;
    pav:version "1.4" .
  
  sub:_7 prov:value """TABLE 4 Downregulated genes in HMEC-4 cells after treatment with S100b Gene name AN Fold change Potential function  -------------------------------------------------------------------------------- Stress response proteins Metallothionein 1E 					M10942 		-2.3 Binds toxic metals and scavenges free radicals Similar to metallothionein 1E 			AL031602 	-2.6 See function of metallothionein 1E Selenoprotein W, 1 (SEPW1) 				NM_003009 	-2.1 Antioxidant Enzymes RNA polymerase II (DNA directed) polypeptide A 	NM_000937 	-2.7 Largest subunit of RNA polymerase II (220 kD) Short-chain dehydrogenase reductase 1 (SDR1) 	NM_004753 	-2.5 Regeneration of retinol (Vit. A) from retinal Highly similar to transglutaminase 2 		BC003551 	-2.2 99% identical to transglutaminase 2, a protein cross-linking enzyme Ubiquitin protein ligase E3A 			NM_000462 	-2.0 Protein ubiquitination Mitochondrial proteins Glutaminase C 					AF158555 	-2.4 Converts L-glutamine to L-glutamate Cytoskeletal-associated protein Caldesmon 1 (CALD1) 					NM_033157 	-2.0 Actomyosin regulatory protein Other proteins RNA binding protein BRUNOL3 				U69546 		-2.0 Translation repression Clone 24775 						AF052169 	-2.1 Role unknown In contrast, the alternate RAGE ligand, S100b, triggered an increase in endothelial mRNA expression of a variety of immune-related genes.""";
    prov:wasQuotedFrom pubmed:14988260 .
  
  sub:_8 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:14988260;
    prov:wasDerivedFrom beldoc:, sub:_7 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:21.029+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}