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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAbddolV-YYOwXNevKAENzlxnf12tzE40kplCU6KLDxUE#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAbddolV-YYOwXNevKAENzlxnf12tzE40kplCU6KLDxUE#_5 http://www.w3.org/ns/prov#value After binding of ligand, either estrogens or antiestrogens, to the ER, the receptor dimerizes with another receptor-monomer to somehow activate the complex and to facilitate the binding of the receptor dimer to the EREs of target genes... ERalpha and ERbeta can heterodimerize, and ERbeta appears to have different functional properties Other nuclear proteins can interact with the ER dimer to modify the expression of certain genes...Some of these receptor-interacting proteins function as co-activators to amplify transcription activation from the ER, while others function as co-repressors. 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