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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4#_7 http://www.w3.org/ns/prov#value the SGK promoter contains consensus DNA elements for Smad and Fast-1 binding (hatched boxes labeled SMAD 3/4 and Fast-1 in figure 2) that are activated by TGF-beta receptor signaling, This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed. http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12649597 http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12649597 http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4#_7 http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4 http://purl.org/dc/terms/created 2014-07-03T14:30:11.250+02:00 http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAcAhf2EdmYrLCgH7smvyZxSQaxYC78J8Hop7GQ66boZ4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234