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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s#_4 http://www.w3.org/ns/prov#value Besides its direct angiogenic role, other potential mechanisms of the angiogenic function of IL-18 may be through IL-8 and other angiogenic cytokines that it up-regulates. Indeed, IL-18 exerts an inflammatory cytokine cascade in the mixed PBMC population by stimulating the constitutive expression of IL-18R on NK cells and lymphocytes, which leads to TNF-a production, ultimately stimulating macrophage IL-1b and IL-8 production (19). In turn, treatment with IL-1b and TNF-a of RA synovial fibroblast cultures, not constitutively expressing IL-18, induced IL-18 gene and protein production, suggesting a feedback interaction to promote Th1 cytokine and cell development in RA (21). http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11466388 http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11466388 http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s#_4 http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s#pubinfo http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s http://purl.org/dc/terms/created 2014-07-03T14:29:57.517+02:00 http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAcEzcbVtoZ729Asn1AWlV6D76_NUrH9hfcs1EU15B32s http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234