http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#Head http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#assertion http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#provenance http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#assertion http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_2 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_2 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-protein-families/Prkc%20Family http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_3 http://www.selventa.com/vocabulary/variantOf http://www.informatics.jax.org/marker/MGI:98783 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D006321 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_3 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_1 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(PFM:"Prkc Family")) -> p(MGI:Tnni3,pmod(P,S,23)) http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_5 http://www.w3.org/ns/prov#value Within the cardiac isoform's amino-terminal extension, serines are present at residues 23 and 24 (Ser23/Ser24), which serve as substrates for protein kinase A (PKA), which is activated in response to ?-adrenergic stimulation of the heart (3). Several investigations report that PKA-mediated phosphorylation of cTnI results in a reduction in myofilament Ca2+ sensitivity (4), an increase in cross-bridge cycling (5), and increased binding of cTnI to the thin filament. Cardiac TnI is also a substrate for protein kinase C (PKC) phosphorylation at Ser43/Ser45 and Thr144 (position 143 in the human protein) (6). However, the substrate specificity of these sites is not absolute, since PKC can phosphorylate the PKA sites (7-9). http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15507454 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15507454 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#_5 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ http://purl.org/dc/terms/created 2014-07-03T14:30:28.925+02:00 http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAcNHZZAb3C3zPgvDOmFfXOOXbSBJNvTO0mCFf3vlqXNQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234