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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60#_7 http://www.w3.org/ns/prov#value In this study, we show that a p160 coactivator contributes to the ligand- independent ER activation of a target gene in a cellular model in which ER, coactivator, and target gene are endogenous. Using transfected cells, we further show that the full-length ER can interact physically and functionally with all three p160/SRCs and CBP in the absence of ligand in vivo and that mutation of Ser104/106/118 to Ala residues in ER affects these interactions. In addition, mutation of these residues affects ER coactivation by a subset of coactivators in the presence of E2, albeit to a lesser extent than in the absence of hormone. Further analysis reveals that mutations of both Ser104/106 and Ser118 decrease ligand-independent SRC-1 coactivation of ER activity by two mechanisms. First, there is a seemingly indirect effect on SRC-1 recruitment that, surprisingly, requires other receptor domains in addition to A/B, which is consistent with our finding that SRC-1 enhancement of the ligand- independent interaction between the A/B and DEF regions is regulated by the Ser104/106/118 phosphorylation sites. Secondly, we observe an effect on SRC-1 coactivation of the A/B domain that does not depend on the remainder of the molecule. further show that the full-length ER can interact physically and functionally with all three p160/SRCs and CBP in the absence of ligand in vivo http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12714702 http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12714702 http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60#_7 http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60#pubinfo http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60 http://purl.org/dc/terms/created 2014-07-03T14:30:12.023+02:00 http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAcPJUHBy3NXQ4wx-rYSXIp6H1SesxLQqeFYOOMwEwP60 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234