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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAcX5iGMyDNl7aQyTCsTToSgF4EX_HapMGLVPE5XbFHdw#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAcX5iGMyDNl7aQyTCsTToSgF4EX_HapMGLVPE5XbFHdw#_4 http://www.w3.org/ns/prov#value NF-?B also controls expression of other genes, the activities of which are linked to the invasive and metastatic behavior of cancer cells (Fig. 1). For example, NF-?B regulates expression of matrix metalloproteinase-9 (MMP-9), which is responsible for the degradation of tissue barriers [37]; cyclin D1, a cell cycle regulatory protein, which stimulates dysregulation of the cell cycle and tumor formation [38]; cell survival proteins Bcl-2 and BclXL, which protect against apoptosis of cancer cells [39]; and vascular endothelial growth factor (VEGF), which is a potent angiogenic factor stimulating tumor growth [40]. 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