sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_5 ; pav:version "1.4" . sub:_4prov:value "However, other groups have not found an improvement in the differentiation capacity of brown pre-adipocytes upon inhibition of MAPK (Fasshauer et al. 2001). In addition to adipogenesis, insulin and IGF-I are novel thermogenic factors through the ability to increase UCP- 1 gene transcription rate and also UCP-1 mRNA accumulation (Lorenzo et al. 1993). Moreover, insulin and IGF-I transactivate the fusion gene containing the UCP-1 full promoter controlling the reporter gene chloramphenicol acetyl transferase (CAT), in a tissue-specific manner. Inhibition of PI3K with LY294002 completely blocked insulin/IGF-I-induced transactivation of the UCP-1 promoter and UCP-1 mRNA accumulation (Teruel et al. 1998)." ; prov:wasQuotedFrompubmed:15777261 . sub:_5rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:15777261 ; prov:wasDerivedFrombeldoc: , sub:_4 . }