@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAcdoI93Gqj45WLBlg3TeJQh4_Dp89phCDnRnn70Fp40k> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAcdoI93Gqj45WLBlg3TeJQh4_Dp89phCDnRnn70Fp40k#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix nch: <http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  nch:p85%2Fp110%20PI3Kinase%20Complex a ProteinComplex: .
  
  sub:_1 hasAgent: nch:p85%2Fp110%20PI3Kinase%20Complex;
    a go:0016301 .
  
  sub:_2 geneProductOf: hgnc:12517;
    a RNA: .
  
  sub:_3 occursIn: mesh:D017667, species:9606;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "kin(complex(NCH:\"p85/p110 PI3Kinase Complex\")) -> r(HGNC:UCP1)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "1.4" .
  
  sub:_4 prov:value "However, other groups have not found an improvement in the differentiation capacity of brown pre-adipocytes upon inhibition of MAPK (Fasshauer et al. 2001). In addition to adipogenesis, insulin and IGF-I are novel thermogenic factors through the ability to increase UCP- 1 gene transcription rate and also UCP-1 mRNA accumulation (Lorenzo et al. 1993). Moreover, insulin and IGF-I transactivate the fusion gene containing the UCP-1 full promoter controlling the reporter gene chloramphenicol acetyl transferase (CAT), in a tissue-specific manner. Inhibition of PI3K with LY294002 completely blocked insulin/IGF-I-induced transactivation of the UCP-1 promoter and UCP-1 mRNA accumulation (Teruel et al. 1998).";
    prov:wasQuotedFrom pubmed:15777261 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15777261;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:33.517+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}