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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAcdoI93Gqj45WLBlg3TeJQh4_Dp89phCDnRnn70Fp40k#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAcdoI93Gqj45WLBlg3TeJQh4_Dp89phCDnRnn70Fp40k#_4 http://www.w3.org/ns/prov#value However, other groups have not found an improvement in the differentiation capacity of brown pre-adipocytes upon inhibition of MAPK (Fasshauer et al. 2001). In addition to adipogenesis, insulin and IGF-I are novel thermogenic factors through the ability to increase UCP- 1 gene transcription rate and also UCP-1 mRNA accumulation (Lorenzo et al. 1993). Moreover, insulin and IGF-I transactivate the fusion gene containing the UCP-1 full promoter controlling the reporter gene chloramphenicol acetyl transferase (CAT), in a tissue-specific manner. 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