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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q#_5 http://www.w3.org/ns/prov#value PIMT (PRIP-interacting protein with methyltransferase domain), an RNA-binding protein with a methyltransferase domain capable of binding S-adenosylmethionine, has been shown previously to interact with nuclear receptor coactivator PRIP (peroxisome proliferator-activated receptor (PPAR)-interacting protein) and enhance its coactivator function. We now report that PIMT strongly interacts with transcriptional coactivators, CBP, p300, and PBP but not with SRC-1 and PGC-1alpha under in vitro and in vivo conditions. The PIMT binding sites on CBP and p300 are located in the cysteine-histidine-rich C/H1 and C/H3 domains, and the PIMT binding site on PBP is in the region encompassing amino acids 1101-1560. The N-terminal of PIMT (residues 1-369) containing the RNA binding domain interacts with both C/H1 and C/H3 domains of CBP and p300 and with the C-terminal portion of PBP that encompasses amino acids 1371-1560. The C-terminal of PIMT (residues 611-852), which binds S-adenosyl-l-methionine, interacts respectively with the C/H3 domain of CBP/p300 and with a region encompassing amino acids 1101-1370 of PBP. Immunoprecipitation data showed that PIMT forms a complex in vivo with CBP, p300, PBP, and PRIP. PIMT appeared to be co-localized in the nucleus with CBP, p300, and PBP. PIMT enhanced PBP-mediated transcriptional activity of the PPARgamma, as it did for PRIP, indicating synergism between PIMT and PBP. In contrast, PIMT functioned as a repressor of CBP/p300-mediated transactivation of PPARgamma. Based on these observations, we suggest that PIMT bridges the CBP/p300-anchored coactivator complex with the PBP-anchored coactivator complex but differentially modulates coactivator function such that inhibition of the CBP/p300 effect may be designed to enhance the activity of PBP and PRIP. http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11912212 http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11912212 http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q#_5 http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q#pubinfo http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q http://purl.org/dc/terms/created 2014-07-03T14:30:02.026+02:00 http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAcq1jMijAE9hkc7tsuG1vdw2SFgNyxR2Q58c8EZD0P6Q http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234