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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE#_4 http://www.w3.org/ns/prov#value The binding of AP-1 to the relevant promoter sequence depended on the presence of STAT4. STAT4 bound with c-Jun, and a phosphorylated c-Jun-STAT4 complex most efficiently interacted with the AP-1-relevant promoter sequence. Enhanced cobinding of STAT4 and c-Jun to the AP-1 sequence was also observed when activated lymph node T cells were exposed to IL-12 plus IL-18. These results show that STAT4 up-regulates AP-1-mediated IFN-gamma promoter activation without directly binding to the promoter sequence, providing a mechanistic explanation for IL-12/IL-18-induced synergistic enhancement of IFN-gamma gene expression. http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11801649 http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11801649 http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE#_4 http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE http://purl.org/dc/terms/created 2014-07-03T14:30:00.501+02:00 http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAcxqWcIxYEEJf-AQqxVM2JbRF4_H38Tg9HcrRp37-NtE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234